Mesothelioma is a rare form of cancer primarily caused by asbestos exposure. There is a higher incidence of mesothelioma among U.S. Navy personnel, shipyard workers, etc. due to asbestos exposure on Navy ships. In addition, family members and others closely associated to those exposed to asbestos may also be at risk (for example the wife who washed her husband's work clothes). The cancer typically has a latency period of 20 to 50 years.

The mesothelium is a membrane that covers and protects most of the internal organs of the body. It is composed of two layers of cells: One layer immediately surrounds the organ; the other forms a sac around it. The mesothelium produces a lubricating fluid that is released between these layers, allowing moving organs (such as the beating heart and the expanding and contracting lungs) to glide easily against adjacent structures.

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